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OSTEOMYELITIS / SEPTIC ARTHRITIS |
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| Clinical conditions | Pathogen(s) | Antibiotic(s) | Comments |
| Acute osteomyelitis | Staph. aureus |
Flucloxacillin IV 2g qds 2 weeks minimum IV followed by oral therapy Total course 4-6 weeks If penicillin allergy clindamycin 600mg qds |
Seek specialist advice Consider referral for outpatient parenteral therapy (OHPAT).
|
| Chronic osteomyelitis | Staph. aureus Occasionally coliforms |
Oral flucloxacillin If MRSA or penicillin allergy Oral doxycycline or co-trimoxazole (check sensitivites) |
If coliforms
suspected – seek specialist advice.
|
| MRSA osteomyelitis | MRSA |
Vancomycin IV Dosing as per
local guidance |
Seek
specialist advice.
|
| Acute septic
arthritis (see AMAU/Rheum guidance document)
|
Staph. aureus |
IV flucloxacillin 2g qds for 2 weeks then oral therapy Total course 4-6 weeks If penicillin allergy clindamycin 600mg qds |
May require washout Consider Neisseria spp and in young adults consider Chlamydia spp also |
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© 2010 NHS Tayside
