SEPSIS

Clinical conditions Pathogen(s) Antibiotic(s) Comments
Sepsis in non-neutropenic 
patient                             
E.coli
Strep. pneumoniae
Staph. aureus
Others

Refer to Hospital Antibiotic Adult if source known or suspected otherwise start:

IV Amoxicillin + Metronidazole + Gentamicin

Complete Sepsis 6 bundle and start antimicrobial therapy within 1 hour.

If penicillin allergic IV Vancomycin + Metronidazole + Gentamicin

Sepsis in neutropenic
patient

Coliforms
Pseudomonas
Staphylococci

Viridans streptococci

Haematology Patient

Oncology Patient

Non Haem/Onc Patient

Sepsis in patients with intravascular catheter in situ

Staph. epidermidis
Staph. aureus

Flucloxacillin 2g IV qds Consider removing the catheter.  Consider also changing to IV vancomycin if no improvement or if MRSA/MRSE is isolated in blood culture or patient is known to be MRSA positive or previous line infection with MRSA/MRSE.

If confirmed S. aureus bacteraemia (SAB) refer to national guidance

Antifungal therapy - click here

 

Approved by AMG: February 2020
Review: February 2023

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