Gastroenterology Specialist formulary list

**Other indications for particular drugs may be included on completion of further specialist lists**

For information on use of unlicensed medicines or medicines used 'off-label' - click here

The following medicines are approved for prescribing by or on the recommendation of a prescribing gastroenterology specialist:

MEDICINE SUMMARY OF RESTRICTED INDICATION CATEGORY PROTOCOL
Esomeprazole for intravenous infusion Prevention of re-bleeding following therapeutic endoscopy for severe bleeding gastric or duodenal ulcers.

Guidance for Management of Upper GI Bleed on the Acute Medical Unit (NHS Tayside Staffnet intranet link only)

See SIGN 105 Management of acute upper and lower gastrointestinal bleeding

Sucralfate liquid (Antepsin®) Prevention of re-bleeding following oesophageal/gastric variceal banding (unlicensed use ‘off-label’).  
Sulfasalazine Induction and maintenance of remission of ulcerative colitis; treatment of active Crohn's Disease.

Gastroentereology GP letter - sulfasalazine

Methylprednisolone intravenous injection or infusion (Solu-Medrone®) Severe exacerbation of inflammatory bowel disease (IBD).  
Azathioprine tablets

Steroid dependent ulcerative colitis (UC) or Crohn’s disease or where there are frequent relapses or severe disease (unlicensed use ‘off-label’).

Shared care Agreement – Azathoprine/Mercaptopurine for inflammatory bowel disease  (NHS Tayside Staffnet intranet link only)

Mercaptopurine tablets

Steroid dependent UC or Crohn’s disease or where there are frequent relapses or severe disease (alternative where azathioprine has been beneficial but patient unable to tolerate side effects)(unlicensed use ‘off-label’).

Mercaptopurine is an option where azathioprine has been beneficial but patient is unable to tolerate its side effects.

Budesonide gastro-resistant capsules 3mg (Budenofalk®) Symptomatic relief of chronic diarrhoea in those with collagenous colitis  
Budesonide gastro-resistant granules 9mg (Budenofalk®) Symptomatic relief of chronic diarrhoea in those with collagenous colitis  
Methotrexate intramuscular or subcutaneous injection (Metoject®) ONCE WEEKLY Induce remission in severe Crohn’s disease (unlicensed use ‘off-label’).
Note:
May be administered in primary care.

Gastroenterology GP letter - methotrexate

Gastroenterology Guidelines for GPs – methotrexate

(NHS Tayside Staffnet intranet links only)

Methotrexate (oral) 2.5mg tablets ONCE WEEKLY Maintenance of remission in severe Crohn’s disease (unlicensed use ‘off-label’)

 

VSL#3® powder Treatment resistant pouchitis – see protocol. Local Treatment Protocol  (NHS Tayside Staffnet intranet link only)
Adalimumab▼  subcutaneous injection Treatment of severe active Crohn’s disease which has not responded to a full and adequate course of therapy with a corticosteroid and /or immunosuppressant; or who are intolerant to or have contraindications to such therapies. NICE MTA 187

Infliximab intravenous infusion

Alternative to adalimumab in patients with fistulating Crohn's disease or issues with compliance to weekly/fortnightly adalimumab therapy at home.

 
Rifaximin (Targaxan®)

Reduction in recurrence of episodes of overt hepatic encephalopathy (HE) in patients ≥18 years of age. Second line - in combination with lactulose, after standard lactulose therapy.

Local treatment protocol  (NHS Tayside Staffnet intranet link only)
Propranolol (oral) Primary or secondary prophylaxis of variceal bleeding in portal hypertension. See SIGN 105 Management of acute upper and lower gastrointestinal bleeding
Carvedilol tablets Alternative to propranolol (if not tolerated) for primary or secondary prophylaxis of variceal bleeding in portal hypertension (unlicensed use ‘off-label’).
Terlipressin acetate intravenous injection (Variquel®) Bleeding from oesophageal varices.

Guidance for Management of Upper GI Bleed on the Acute Medical Unit (NHS Tayside Staffnet intranet link only)

See SIGN 105 Management of acute upper and lower gastrointestinal bleeding

Ferric carboxymaltose (Ferinject®▼)

Treatment of iron deficiency anaemia when oral iron preparations are ineffective or cannot be used. Restricted to administration by intravenous infusion.  
Dioralyte® double strength solution (10 sachets in 1L) (Unlicensed use ‘off label) Electrolyte disturbance in those with intestinal failure and high output stomas. Guidelines for Management of Patients with a Short Bowel (GUT 2006)
Magnesium glycerophosphate 1g (4mmol) tablets (unlicensed) (made by UCLH supplied by IDIS) Hypomagnesaemia  

Selenium-ACE®

Selenium and vitamin A, C & E deficiency in prolonged parenteral nutrition.  

Pabrinex® I/V High Potency injection

Prophylaxis and treatment of Wernicke-Korsakoff syndrome or in patients receiving artificial nutrition.  

Co-trimoxazole (oral)

Treatment and prophylaxis of Spontaneous Bacterial Peritonitis (SBP) (unlicensed use ‘off-label’).

Antibiotic prophylaxis for variceal bleeding in patients with liver cirrhosis (unlicensed use ‘off-label’).

 

Antimicrobial Treatment and Prophylaxis of Spontaneous Bacterial Peritonitis and Antibiotic Prophylaxis for Variceal Bleeding in Patients with Liver Cirrhosis protocol

See SIGN 105 Management of acute upper and lower gastrointestinal bleeding

Piperacillin with tazobactam injection for intravenous infusion

Severe Spontaneous Bacterial Peritonitis (SBP) with step down to co-trimoxazole to complete course when clinically improved (if patient usually on prophylaxis give complete course as piperacillin with tazobactam).

The following medicines are approved for prescribing by or on the recommendation of a prescribing gastroenterology or infectious diseases specialist in Blood Borne Viruses:

MEDICINE SUMMARY OF RESTRICTED INDICATION CATEGORY PROTOCOL

Peginterferon alfa-2a (Pegasys®)

 
Monotherapy in chronic hepatitis B infection. In combination with ribavirin for chronic hepatitis C infection (monotherapy if ribavirin not tolerated or contra-indicated).

Tayside BBV Managed Care Network Hepatitis B (HBV) Clinical Guidelines

NHS Tayside Hepatitis B Quick Reference Guide for Primary Care

Tayside BBV Managed Care Network Clinical Guidelines for the Management of Hepatitis C

NHS Tayside Hepatitis C Quick Reference Guide for Primary Care

Peginterferon alfa-2b (ViraferonPeg®)

In combination with ribavirin for chronic hepatitis C (monotherapy if ribavirin not tolerated or contra-indicated).

Tayside BBV Managed Care Network Clinical Guidelines for the Management of Hepatitis C

NHS Tayside Hepatitis C Quick Reference Guide for Primary Care

Ribavirin capsules, oral solution (Rebetol®) Chronic hepatitis C in combination with peginterferon alfa.
Eltrombopag tablets (Revolade®) Thrombocytopenia in patients with chronic hepatitis C infection where thrombocytopenia is inhibiting optimal interferon-based therapy.  
Telaprevir tablets (Incivo®▼)

First-line protease inhibitor. In combination with peginterferon alfa and ribavirin, for the treatment of genotype 1chronic hepatitis C in adult patients with compensated liver disease who are treatment-naïve or have previously been treated with interferon alfa alone or in combination with ribavirin, including relapsers, partial responders and null responders.

 

Tayside BBV Managed Care Network Clinical guidelines for the use of protease inhibitors for the treatment of hepatitis C genotype 1

Drug interactions are common particularly with protease inhibitors for Hepatitis C.

Please check http://www.hep-druginteractions.org or seek advice before prescribing.

Add Hepatitis C medication to all electronic patient medication records and GP records.

Boceprevir capsules (Victrelis®▼)

Treatment of chronic hepatitis C genotype 1 infection, in combination with peginterferon and ribavirin, in adult patients with compensated liver disease who are previously untreated or who have failed previous therapy.

Simeprevir 150mg hard capsules (Olysio®) In combination with other treatments for chronic hepatitis C genotype 1 or 4.  Treatment combinations and duration of therapy are dependent upon whether patients are treatment-naive and prior relapse, prior non-responder patients (including partial and null responders), or intolerant to or ineligible for interferon therapy and are in urgent need of treatment.
Sofosbuvir tablets (Sovaldi®▼) In combination with other treatments for the treatment of chronic hepatitis C in adults. Indicated for dual or triple therapy for 12 or 24 weeks depending on patient’s genotype and whether unsuitable for or intolerant to peginterferon based therapy. Use in treatment-naïve patients with genotype 2 or 24-week (interferon free) regimen restricted to those unsuitable for, or unable to tolerate peginterferon alfa.
Tenofovir disoproxil tablets (Viread®▼) Chronic hepatitis B infection with either compensated liver disease or decompensated liver disease. First line treatment.

Tayside BBV Managed Care Network Hepatitis B (HBV) Clinical Guidelines

NHS Tayside Hepatitis B Quick Reference Guide for Primary Care

Lamivudine tablets (Zeffix®) Chronic hepatitis B infection either with compensated or decompensated liver disease when first-line treatments cannot be used.
Adefovir dipivoxil tablets (Hepsera®) Chronic hepatitis B infection with either compensated liver disease or decompensated liver disease in lamivudine resistant patients in whom interferon has failed, is contra-indicated or not tolerated.
Entecavir tablets (Baraclude®▼) Alternative to adefovir in chronic hepatitis B infection with compensated liver disease in lamivudine resistant patients in whom interferon has failed, is contra-indicated or not tolerated.

 

Traffic light status information
 To be prescribed by Hospital Specialists Only.
 Can be prescribed in General Practice under the direction of a Specialist.

For further information on local gastroenterology clinical guidelines see the Acute Medicine Unit website on Staffnet – click here (NHS Tayside Staffnet intranet link only).  

For further information on treatment of gastrointestinal infections refer to the NHS Tayside Guide to Antibiotic Use website – click here

For information or guidelines on Hepatitis B or C see the NHS Tayside Blood Borne Virus Managed Care Network website – click here.

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