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13.10 Anti-infective skin preparations

Antibacterial Preparations 

Antibacterials not used systemically

Silver sulfadiazine cream 1%
Dose:
Apply with sterile applicator; burns, apply daily or more frequently if very exudative; leg ulcers or pressure sores apply daily or on alternate days (not recommended if ulcer is very exudative); finger tip injuries, apply every 2-3 days.
 

Antibacterials also used systemically

Fusidic acid cream, ointment, gel 2%
Dose:
Apply 3 to 4 times daily for up to 7 days.

Metronidazole cream, gel 0.75%
Dose: Acute inflammatory exacerbation of acne rosacea, apply thinly twice-daily for 8-9 weeks; avoid contact with eyes.

Antifungal preparations

FIRST CHOICE:       CLOTRIMAZOLE cream

Clotrimazole cream 1%
Dose: Apply 2-3 times daily, continuing for 14 days after lesions have healed.

Ketoconazole cream 2%
Dose:
Apply 1-2 times daily

NB Only prescribable for seborrhoeic dermatitis and pityriasis versicolor. Endorse SLS.

Miconazole cream 2%
Dose: Apply twice-daily continuing for 10 days after lesions have healed.

Terbinafine cream 1%
Dose: Apply thinly 1-2 times daily for up to 1 week in tinea pedis, 1 to 2 weeks in tinea corporis and tinea cruris, 2 weeks in cutaneous candidiasis and pityriasis versicolor; review after 2 weeks.  Not recommended for children.
 

Antiviral preparations

Aciclovir cream 5%
Dose: Apply to herpes simplex lesions every 4 hours (5 times daily) for 5 days, started at first sign of attack.
 

Treatment of lice and scabies

Dimeticone 4% lotion
Dose:  Head lice, rub into dry hair and scalp, allow to dry naturally, shampoo after a minimum of 8 hours (or overnight); repeat application after 7 days.

Malathion 0.5% in aqueous basis
Dose:
  Head lice, rub into dry hair and scalp, allow to dry naturally, remove by washing after 12 hours and repeat treatment after 7 days. Crab/pubic lice, apply aqueous preparation to all parts of the body (not merely the groin and axillae) for 12 hours, or overnight; a second treatment needed after 7 days to kill lice emerging from surviving eggs.

Several products are available which require the use of a fine tooth plastic detection comb and hair conditioner; a head lice device (Bug Buster® Kit) is prescribable on the NHS.  The methods typically involve meticulous combing with the detection comb over the whole scalp at 4 day intervals for at least 2 weeks.

Permethrin cream 5%
Dose:
  Scabies: apply over whole body including face, neck and ears and wash off after 8 to 12 hours. Those with sparse hair should also apply the cream to their scalp.  If hands are washed with soap and water within 8 hours of application, cream should be re-applied.  Repeat treatment after 7 days.  All members of household/close contacts should be treated once only.
 

Refer to notes on “treatment of scabies” click here 

For further information on scabies see the Scabies Dermatology Referral and Management Pathway.

13.1   Vehicles
13.2   Emollients and barrier preparations
13.3   Anti-pruritic preparations and topical local anaesthetics and topical local anaesthetics 
13.4   Topical corticosteroids
13.5.1 Eczema
13.5.2 Psoriasis
13.5.3 Drugs affecting the immune response
13.6   Preparations for Acne and Rosacea
13.7   Preparations for Warts
13.8   Sunscreens
13.9   Shampoos and scalp applications
13.11 Skin cleansers, antiseptics, and desloughing agents
13.12 Hyperhidrosis
13.13 Circulatory preparations

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