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13.12
Hyperhidrosis
Hyperhidrosis is excessive sweating. It can be localised or affect the whole body. Refer to the Department of Dermatology Hyperhidrosis Guideline for further background information and management. The following medicines may be used in the treatment of hyperhidrosis (refer to guideline for place in therapy in relation to severity):
Topical treatments
FIRST CHOICE: ALUMINIUM ANTIPERSPERANTS (Anhydrol Forte®, Driclor®)
Aluminium antiperspirants - Anhydrol Forte®, Driclor®
Aluminium chloride hexahydrate 10% in 4% salicylic gel [unlicensed]
Aluminium chloride hexahydrate 20% in 4% salicylic gel [unlicensed]
Glycopyrrolate 2% in Unguentum M®, 100g [unlicensed]
Glycopyrrolate 2% in Aqueous Solution, 100ml [unlicensed]
In more severe cases specialists use iontophoretic treatment for hyperhidrosis of plantar and palmar areas. Tap water or Glycopyrronium bromide 0.05% solution [unlicensed] may be used as the iontophoresis solution.
Systemic treatments
Systemic treatments for hyperhidrosis include oral medicines: the anticholinergics: oxybutynin [unlicensed use ‘off-label’] and propiverine hydrochloride [unlicensed use ‘off-label’]; the beta-blocker: propranolol [unlicensed use ‘off-label’] or an SSRI such as fluoxetine [unlicensed use ‘off-label’]. Refer to Hyperhidrosis Guideline for information on doses used.
Botulinum Toxin Type A (Botox®) is licensed for use intradermally for severe hyperhidrosis of the axillae unresponsive to topical antiperspirant or other antihidrotic treatment. Refer to the Department of Dermatology Hyperhidrosis Guideline for further information.
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