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13.12 Hyperhidrosis

Hyperhidrosis is excessive sweating. It can be localised or affect the whole body.  Refer to the Department of Dermatology Hyperhidrosis Guideline  for further background information and management. The following medicines may be used in the treatment of hyperhidrosis (refer to guideline for place in therapy in relation to severity):

Topical treatments

FIRST CHOICE:   ALUMINIUM ANTIPERSPERANTS (Anhydrol Forte®, Driclor®)

Aluminium antiperspirants - Anhydrol Forte®, Driclor®

   Aluminium chloride hexahydrate 10% in 4% salicylic gel [unlicensed]

    Aluminium chloride hexahydrate 20% in 4% salicylic gel [unlicensed]

      Glycopyrrolate 2% in Unguentum M®, 100g [unlicensed]

    Glycopyrrolate 2% in Aqueous Solution, 100ml [unlicensed]

In more severe cases specialists use iontophoretic treatment for hyperhidrosis of plantar and palmar areas. Tap water or Glycopyrronium bromide 0.05% solution [unlicensed] may be used as the iontophoresis solution.

Systemic treatments

Systemic treatments for hyperhidrosis include oral medicines: the anticholinergics:  oxybutynin [unlicensed use ‘off-label’] and  propiverine hydrochloride [unlicensed use ‘off-label’]; the beta-blocker: propranolol [unlicensed use ‘off-label’] or an SSRI such as  fluoxetine [unlicensed use ‘off-label’]. Refer to Hyperhidrosis Guideline  for information on doses used.

    Botulinum Toxin Type A (Botox®) is licensed for use intradermally for severe hyperhidrosis of the axillae unresponsive to topical antiperspirant or other antihidrotic treatment.  Refer to the Department of Dermatology Hyperhidrosis Guideline  for further information.

13.1   Vehicles
13.2   Emollients and barrier preparations
13.3   Anti-pruritic preparations and topical local anaesthetics and topical local anaesthetics 
13.4   Topical corticosteroids
13.5.1 Eczema
13.5.2 Psoriasis
13.5.3 Drugs affecting the immune response
13.6   Preparations for Acne and Rosacea
13.7   Preparations for Warts
13.8   Sunscreens
13.9   Shampoos and scalp applications
13.10   Anti-infective skin preparations
13.11 Skin cleansers, antiseptics, and desloughing agents
13.13 Circulatory preparations

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